Literature Review

DHPS



Evolution of the DHPS Gene

DHPS is highly conserved in plants and eukaryotes, which means that it plays an important role in cell function. In humans, the gene coding for human deoxyhypusine synthase (DHPS) maps to chromosome 19.

  • Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes.(PMID: 19254800,(ncbi.nlm.nih.gov)) Nurhayati N. … Ober D. Phytochemistry 2009 22 64
    • They studied the evolution of plant secondary metabolism pathways, using pyrrolizidine alkaloids as a model system. The gene encoding Homospermidine synthase was recruited from the gene encoding deoxyhypusine synthase from primary metabolism at least four times independently during angiosperm evolution.
  • Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification. (PMID: 17476569,(ncbi.nlm.nih.gov)) Wolff E.C. … Park M.H. Amino Acids 2007 3 22 64
    • The hypusine synthetic pathway has evolved in eukaryotes is highly conserved, suggesting maintenance of a fundamental cellular function of eIF5A through evolution.
  • Horizontal gene transfer and archaeal origin of deoxyhypusine synthase homologous genes in bacteria. (PMID: 15087136,(ncbi.nlm.nih.gov)) Brochier C. … Moreira D. Gene 2004 22 64
    • The phylogenetic analysis of DHPS gene sequences strongly suggests that they have been acquired from archaea by horizontal gene transfer.
  • Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase. (PMID: 12620346,(ncbi.nlm.nih.gov)) Ober D. … Hartmann T.Phytochemistry 2003 22 64
    • Plant homospermidine synthase is phylogenetically derived from DHPS; it represents a DHPS having lost its intrinsic activity.
  • Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein.(PMID: 12562768,(ncbi.nlm.nih.gov)) Ober D. … Hartmann T. J. Biol. Chem. 2003 3 64
    • Homospermidine synthase likely evolved from DHPS by gene duplication and being recruited for a new function. Homospermidine synthase behaves like a DHPS that lost its major function (aminobutylation of eIF5A precursor protein) but retained unaltered its side activity (aminobutylation of putrescine).
  • Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids. (PMID: 11197320,(ncbi.nlm.nih.gov)) Ober D. … Hartmann T. Plant Mol. Biol. 2000 22 64
    • DHPS during the evolution of the alkaloid pathway and its evolution are discussed.
  • Cloning and expression of a cDNA encoding homospermidine synthase from Senecio vulgaris (Asteraceae) in Escherichia coli. (PMID: 10476066,(ncbi.nlm.nih.gov)) Kaiser A. Plant J. 1999 22 64
    • To investigate the evolutionary function of DHPS in plants.
  • Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. (PMID: 9666110,(ncbi.nlm.nih.gov)) Mantuano E. … Jodice C. Gene 1998 3 4 22 64
    • Hypusine is found in all eukaryotes and in some archaebacteria, but not in eubacteria. DHPS cDNA was cloned and mapped by fluorescence in situ hybridization on chromosome 19. Rare cDNAs containing internal deletions were also found. Due to the genomic structure, the internally deleted forms of mature RNA are likely the result of alternative splicing.
  • The gene coding for human deoxyhypusine synthase (DHPS) maps to chromosome 19p13.11-p13.12. (PMID: 8812510,(ncbi.nlm.nih.gov)) Jones T. … Steinkasserer A. Genomics 1996 3 22 64
    • This study determined that the DHPS gene is located on chromosome 19.
  • Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus. (PMID: 8549832,(ncbi.nlm.nih.gov)) Bevec D. … Steinkasserer A. FEBS Lett. 1996 3 4 22 64
    • Researchers isolated two sequences encoding deoxyhypusine synthase from a human peripheral blood mononuclear cells cDNA. The deoxyhypusine synthase gene was determined to be located on human chromosome 19
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