Activation

Phosphorylation of DHPS is CK2-dependent and PKC-mediated. Iron binding is required for DHPS formation.

• Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site. (PMID: 19956996,(ncbi.nlm.nih.gov)) Cano V.S. … Valentini S.R. Amino Acids 2010 22 64
  • Iron binding plays an essential structural role of hypusine formation in the eIF-5A precursorm and it contributes to its catalysis.
• Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells. (PMID: 14749535,(ncbi.nlm.nih.gov)) Kang K.R. … Chung S.I. Exp. Mol. Med. 2003 3 22 64
  • Phosphorylation of DHPS is CK2-dependent cellular event as well as PKC-mediated effect.